Suitability of amoxicillin-clavulanic acid for administration via prolonged infusion
- Submitting institution
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Kingston University
- Unit of assessment
- 12 - Engineering
- Output identifier
- 12-008-1565
- Type
- D - Journal article
- DOI
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10.2147/DDDT.S230459
- Title of journal
- Drug Design, Development and Therapy
- Article number
- -
- First page
- 103
- Volume
- 14
- Issue
- -
- ISSN
- 1177-8881
- Open access status
- Compliant
- Month of publication
- -
- Year of publication
- 2020
- URL
-
-
- Supplementary information
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-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- Yes
- Number of additional authors
-
-
- Research group(s)
-
-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- With antibiotic resistance on the rise, optimising the dosing regimens through prolonged continuous infusion via elastomeric pumps has potential to optimise the administration of existing antibiotics. This output examines the suitability of amoxicillin-clavulanic for this regimen through temperature dependent stability studies. The data indicated co-amoxiclav stability suitable superior to that previously reported, making it suitable for extended infusion therapy. Another important outcome of these findings is ability to pre-prepare solutions for use in bolus administration, minimising preparation time and workload in the healthcare environment. These findings have clear benefit to human health.
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -