In Vivo Assessment of Bone Regeneration in Alginate/Bone ECM Hydrogels with Incorporated Skeletal Stem Cells and Single Growth Factors
- Submitting institution
-
De Montfort University
- Unit of assessment
- 3 - Allied Health Professions, Dentistry, Nursing and Pharmacy
- Output identifier
- 3073
- Type
- D - Journal article
- DOI
-
10.1371/journal.pone.0145080
- Title of journal
- PLOS ONE
- Article number
- e0145080
- First page
- -
- Volume
- 10
- Issue
- 12
- ISSN
- 1932-6203
- Open access status
- Out of scope for open access requirements
- Month of publication
- -
- Year of publication
- 2015
- URL
-
-
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
-
15
- Research group(s)
-
-
- Citation count
- 37
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- -
- Author contribution statement
- My role in this collaboration involved developing a formulation for bone regeneration using a hydrogel with the right mechanical properties. The research involved testing different materials and formulations to develop a unique formulation of alginate hydrogel and growth factor loaded PLGA particles (VEGF, TGF, BMP2 and PTHrP). The characterisation involved, mechanical properties, cell viability, SEM, particle size distribution, growth factors loading efficacy and release kinetics. I had to travel to Southampton a few times to deliver the technology and train the project collaborators on the formulation. Later, I worked on data analysis and writing the sections relevant to my contribution.
- Non-English
- No
- English abstract
- -