Impact case study database

Extensive, multidisciplinary LSHTM research on male circumcision underpinned international policy recommendations which led to increased use of VMMC to prevent HIV, especially in sub-Saharan Africa. The researchers’ systematic reviews, meta-analyses and economic modelling studies drew from a wide body of research to directly inform WHO HIV prevention guidance. The impact of these policies, guidance and programmes has been further realised since 2013 by the vast scale-up of VMMC services, and the number of HIV infections avoided.

Pre-REF 2021 background impact

WHO/UNAIDS Operational Guidance (2008) for countries on scaling up VMMC services for HIV prevention was directly informed by LSHTM’s evidence of a strong link between male circumcision and reduced HIV prevalence, as well as evidence that the procedure protected against ulcerative STIs (5.1). In 2011, WHO/UNAIDS with The President’s Emergency Plan for AIDS Relief (PEPFAR), the Bill and Melinda Gates Foundation and the World Bank, published a joint strategic 5-year action framework to accelerate the scale-up of VMMC for HIV prevention in Africa (5.2). This was underpinned by the modelling done by the UNAIDS/ WHO/ SACEMA expert group (including Weiss and White), which highlighted the cost-effectiveness of VMMC and outlined male circumcision as an important HIV prevention strategy, alongside other methods such as condom promotion (5.3). This laid the foundations for subsequent guidelines and policy statements.

Economic and health impacts since 2014 - developing guidelines and setting targets

The 2011 WHO/ UNAIDS strategic framework, based on LSHTM evidence, set a goal of circumcising 80% of males in priority countries by 2016 (approximating 20 million circumcisions), and undertaking an additional 8.4 million circumcisions between 2016 and 2025 (5.2). Achieving this 80% coverage among men aged 15 to 49 in the priority countries was estimated to cost USD1.5 billion, but would result in savings of USD16.5 billion by 2025 due to HIV treatment and care costs which would be avoided. As coverage began to gain pace, in 2015 UNAIDS identified VMMC as a crucial intervention and ‘HIV prevention pillar’ to achieving the global fast-track target of fewer than 500,000 new HIV infections annually by 2020, in line with Sustainable Development Goal (SDG) target 3.3: to end AIDS as a public health threat by 2030, and other SDGs relevant to the HIV response. The 2015 UNAIDS Fast Track Strategy also called for renewed commitment to, sustained funding for, and scaled-up implementation of HIV prevention programmes, including VMMC, in the priority countries in eastern and southern Africa (5.4). The 2016 United Nations political declaration on ending AIDS set a target for an additional 25 million men in the 14 priority countries to be circumcised by 2020 (5.5).

The systematic review of the trial evidence underpinned the updated WHO Guidelines for Preventing HIV through Safe Voluntary Medical Male Circumcision for Adolescent Boys and Men in Generalised HIV Epidemics, published in August 2020 (5.6). Additionally, Weiss was a member of the Guideline Development Group. These guidelines strongly recommended that VMMC continue to be promoted as an additional effective HIV prevention option within combination prevention for adolescents 15 years and older and adult men in settings with generalised epidemics, to reduce the risk of heterosexually acquired HIV infection. The guidelines stated ‘evidence that medical male circumcision reduces a man’s risk of heterosexual acquisition of HIV by 59% from three “gold standard” efficacy trials is supported by strong and consistent evidence of an overall 50% reduction in risk from 17 observational studies in diverse settings, including when implemented alongside ART, with its secondary prevention effect.’ Several LSHTM publications are referenced in the guidelines, contributing to this evidence.

Economic and health impacts since 2014 - saving lives and money

The most recent WHO report in stated that, since the implementation of the 2008 guidance until 2020, nearly 27 million men have been circumcised for HIV prevention in the 15 priority countries in East and Southern Africa: Botswana, Eswatini, Ethiopia, Kenya, Lesotho, Malawi, Mozambique, Namibia, Rwanda, South Africa, South Sudan, Uganda, Tanzania, Zambia and Zimbabwe (5.7). This met the United Nations 2016 commitment of 25 million voluntary male circumcisions by 2020. The majority of the impact of this intervention has been realised since 2014; the latest WHO/ UNAIDS progress report showed that approximately 21 million men were circumcised since then (5.7). This report also demonstrated the long-term impact of VMMC, estimating that if men and boys stopped accessing VMMC today, the number of HIV infections averted would rise to 1.8 million by 2030 and to 5.7 million by 2050; in practice, the benefits are likely to exceed this as programmes continue to provide access to VMMC (5.7). VMMC was found to be highly cost-effective, saving USD1,759 to USD3,300 (depending on targeted age group) per HIV infection in patient treatment and care costs, relative to no VMMC (5.3).

Expanding VMMC for HIV prevention has had direct benefits for female partners of circumcised men, reducing secondary transmission. It also reduces male and female oncogenic STIs such as human papillomavirus (HPV), as well as bacterial vaginosis, and ulcerative STIs (syphilis, herpes simplex virus-2, and chlamydia). These benefits have been evidenced by a comprehensive meta-analysis in 2014 published in the Lancet Global Health which found that VMMC had decreased the incidence of syphilis by 42% in circumcised men compared with uncircumcised men (5.8a). This protective effect was greater for men with HIV, with a reduction of 62%, and female partner syphilis incidence was reduced by 59% overall. There is high-consistency evidence that male circumcision also protects against cervical cancer and cervical dysplasia (5.8b).

Economic and health impacts since 2014 - a focus on safety

To address concerns about the safety of circumcision, efforts were put into developing improved methods and quality standards. As a direct result of her research expertise in this field, Weiss served on the WHO Technical Advisory Group (TAG) on Innovations in Male Circumcision (2010-present) and the WHO VMMC Guidelines development group (2017-2020) which was formed to review more broadly the evidence and policy guidance for scale-up of VMMC (5.9).

In 2013, the TAG, including Weiss, concluded that two specific male circumcision devices were clinically efficacious for male circumcision and safe for healthy adult men when performed by trained providers in public health programmes (provided that surgical backup facilities and skills were available). A subsequent meeting in 2014 confirmed this, and recommended that the devices could be safely used among adolescents aged 13 years and above (5.9). The previously mentioned updated 2020 guidelines recommended the use of WHO-prequalified male circumcision devices as additional methods of male circumcision in the context of HIV prevention for males aged 15 years and older (5.6).