Asymmetric division coordinates collective cell migration in angiogenesis
- Submitting institution
-
King's College London
- Unit of assessment
- 11 - Computer Science and Informatics
- Output identifier
- 111166702
- Type
- D - Journal article
- DOI
-
10.1038/ncb3443
- Title of journal
- Nature cell biology
- Article number
- -
- First page
- 1292
- Volume
- 18
- Issue
- 12
- ISSN
- 1465-7392
- Open access status
- Deposit exception
- Month of publication
- November
- Year of publication
- 2016
- URL
-
-
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- Yes
- Number of additional authors
-
6
- Research group(s)
-
-
- Citation count
- 40
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- Model predictions validated experimentally in vivo here challenged two key dogmas in vascular biology that (1) tip cells do not divide and (2) Notch signalling is critical for selecting tip cells. Generated collaborative transatlantic funding by NSF-BBSRC https://www.nsf.gov/awardsearch/showAward?AWD_ID=1517390&HistoricalAwards=false. Follow-up papers have extended the model and the collaboration (Page et al. Cell Reports 2018, Zakirov, Philosophical Trans Royal Soc. 2021). The paper has also led to a collaboration initiating research on computational modelling of a different tissue where asymmetric division occurs (collaboration with Claudia Linker, Randall Centre for Cell & Molecular Biophysics; includes PhD funding from KCL MRC-DTP 2020).
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -