A quantitative high resolution voxel-wise assessment of myocardial blood flow from contrast-enhanced first-pass magnetic resonance perfusion imaging : microsphere validation in a magnetic resonance compatible free beating explanted pig heart model
- Submitting institution
-
King's College London
- Unit of assessment
- 12 - Engineering
- Output identifier
- 97642652
- Type
- D - Journal article
- DOI
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10.1093/ehjci/jev023
- Title of journal
- European Heart Journal-Cardiovascular Imaging
- Article number
- -
- First page
- 1082
- Volume
- 16
- Issue
- 10
- ISSN
- 2047-2404
- Open access status
- Out of scope for open access requirements
- Month of publication
- March
- Year of publication
- 2015
- URL
-
-
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- Yes
- Number of additional authors
-
13
- Research group(s)
-
-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- This multidisciplinary work builds on the explanted pig heart system and on post-processing techniques for quantitative perfusion imaging developed by our group in the last decade. The study provides gold-standard validation against microspheres for high-resolution quantitative myocardial perfusion by cardiac magnetic resonance (CMR), showing high accuracy of quantification despite the low signal to noise ratio of pixelwise measurements. The results of this study led to the application of quantitative perfusion measurements in routine NHS clinical practice at KCL since 2015, leading to the first prognostic paper [10.1016/j.jcmg.2017.07.022] and to the multicentre adoption of the method in UK and EU centres
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -
