Functional and prognostic significance of the genomic amplification of frizzled receptor 6 ( FZD6 ) in breast cancer
- Submitting institution
-
Brunel University London
- Unit of assessment
- 3 - Allied Health Professions, Dentistry, Nursing and Pharmacy
- Output identifier
- 059-172501-16311
- Type
- D - Journal article
- DOI
-
10.1002/path.4841
- Title of journal
- The Journal Of Pathology
- Article number
- -
- First page
- 350
- Volume
- 241
- Issue
- 3
- ISSN
- 0022-3417
- Open access status
- Compliant
- Month of publication
- November
- Year of publication
- 2016
- URL
-
https://onlinelibrary.wiley.com/doi/full/10.1002/path.4841
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- Yes
- Number of additional authors
-
24
- Research group(s)
-
1 - Biosciences
- Citation count
- 32
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- -
- Author contribution statement
- In this study we have investigated the role of the WNT receptor Frizzled 6 in triple negative breast cancer. The study is original because there was no previous indication that the gene codifying this receptor was altered in breast cancer or played any role in its aggressive behaviour. The study has been conducted using bioinformatic tools, human cell lines and mouse models of breast cancer. The study could potentially lead to the development of new targeted therapies and biomarkers for aggressive subtypes of breast cancer.
- Non-English
- No
- English abstract
- -
