Modified cantilever arrays improve sensitivity and reproducibility of nanomechanical sensing in living cells
- Submitting institution
-
University of York
- Unit of assessment
- 12 - Engineering
- Output identifier
- 65600335
- Type
- D - Journal article
- DOI
-
10.1038/s42003-018-0179-3
- Title of journal
- Communications Biology
- Article number
- 175
- First page
- -
- Volume
- 1
- Issue
- -
- ISSN
- 2399-3642
- Open access status
- Compliant
- Month of publication
- October
- Year of publication
- 2018
- URL
-
-
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- Yes
- Number of additional authors
-
11
- Research group(s)
-
B - Intelligent Systems and Nano-Science
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- This reports the output of a multidisciplinary collaboration: Ndieyira (Bio-chemist), Al-Jehani (Cancer), Kaur (Cancer drugs), Thundat (Physicist), McKendry (Bio-Chemist), and Patil (micro sensing) describing mechanical implications of heterogeneity in cancerous cell environments, using ultra-high sensitivity nano-mechanical sensors to differentiate their interactions with surrounding cells. This interdisciplinary approach, relying on sub-femto molar detection, forms the mechanistic basis to understand the dynamics of cancer cell interactions with their surroundings leading to metastasis. The work has potential to understand the efficacy of cancer drugs, drug resistance and the dynamics of the tumour growth.
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -
