Medial reward and lateral non-reward orbitofrontal cortex circuits change in opposite directions in depression
- Submitting institution
-
The University of Warwick
- Unit of assessment
- 11 - Computer Science and Informatics
- Output identifier
- 6093
- Type
- D - Journal article
- DOI
-
10.1093/brain/aww255
- Title of journal
- Brain
- Article number
- -
- First page
- 3296
- Volume
- 139
- Issue
- 12
- ISSN
- 0006-8950
- Open access status
- Compliant
- Month of publication
- December
- Year of publication
- 2016
- URL
-
-
- Supplementary information
-
-
- Request cross-referral to
- 4 - Psychology, Psychiatry and Neuroscience
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- Yes
- Number of additional authors
-
16
- Research group(s)
-
A - Applied Computing
- Citation count
- 94
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- Research in a top neurology journal reports a major advance in the neural basis of depression: highlighting that depression affects the brain region implicated in non-reward - the lateral orbitofrontal cortex - so sufferers experience a heightened sense of loss and disappointment associated with not receiving rewards. Research received worldwide media coverage and has led to new clinical approaches to treating depression (Downar, Toronto), the understanding of major depressive disorder (Zuo, Chinese Academy of Science), and advances in areas including visual serial reversal learning (Hervig, Cambridge), emotion processing (Wu, Harvard), sleep disruption (Finan, John Hopkins) and childhood depression (Wang, NUS).
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -