Biologically targeted probes for Zn2+: a diversity oriented modular “click-SNAr-click” approach
- Submitting institution
-
University of Keele
- Unit of assessment
- 12 - Engineering
- Output identifier
- 385
- Type
- D - Journal article
- DOI
-
10.1039/C4SC01249F
- Title of journal
- Chemical Science
- Article number
- -
- First page
- 3528
- Volume
- 5
- Issue
- 9
- ISSN
- 2041-6520
- Open access status
- Out of scope for open access requirements
- Month of publication
- June
- Year of publication
- 2014
- URL
-
https://pubs.rsc.org/en/content/articlelanding/2014/sc/c4sc01249f#!divAbstract
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
-
5
- Research group(s)
-
-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- This paper reports organelle targeted fluorescent probes for the detection of zinc developed through an EPSRC DTA studentship supervised by Watkinson and was featured by two media outlets (HeathCanal and PhysOrg.com). It led to further support from the EPSRC (EP/T0073971/1 and EP/R035571/1) and BBSRC (BB/P026788/1). A further six high impact publications have followed this report developing the methodology further, as well as a number of invitations to present at international meetings. The technology has been applied by others to great effect (e.g. Cell Metabolism, 2016, 24, 389-401) and has sought commercial interest in its marketisation by the Swiss-based company Chemodex.
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -
