Designing uniquely addressable Bio-orthogonal Synthetic Scaffolds for DNA and RNA Origami
- Submitting institution
-
University of Newcastle upon Tyne
- Unit of assessment
- 11 - Computer Science and Informatics
- Output identifier
- 238960-176936-1292
- Type
- D - Journal article
- DOI
-
10.1021/acssynbio.6b00271
- Title of journal
- ACS Synthetic Biology
- Article number
- -
- First page
- 1140
- Volume
- 6
- Issue
- 7
- ISSN
- 2161-5063
- Open access status
- Compliant
- Month of publication
- April
- Year of publication
- 2017
- URL
-
https://doi.org/10.1021/acssynbio.6b00271
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- Yes
- Number of additional authors
-
7
- Research group(s)
-
B - Interdisciplinary Computing and Complex Biosystems (ICOS)
- Citation count
- 11
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- DNA origami is used to “fold” a long stretch of a DNA molecule so it can manipulate molecules (e.g. proteins, cancerous cRNA, metal pollutants) in a programmable manner. DNA origami is derived from viral and hence cannot be used in “in vivo” theranostic for humans. The paper demonstrates “bio-orthogonal” origami that is uniquely addressable like a computer memory, guaranteeing that it does not use biologically active components (e.g. genes, proteins) thus opening the door for its use in living organisms. A university spin-out, InfoBiotica, aims to exploit this technology and has already obtained £100K of funding.
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -