3D surface topology guides stem cell adhesion and differentiation
- Submitting institution
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The University of Sheffield
- Unit of assessment
- 12 - Engineering
- Output identifier
- 2649
- Type
- D - Journal article
- DOI
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10.1016/j.biomaterials.2015.01.034
- Title of journal
- Biomaterials
- Article number
- -
- First page
- 140
- Volume
- 52
- Issue
- -
- ISSN
- 0142-9612
- Open access status
- Out of scope for open access requirements
- Month of publication
- February
- Year of publication
- 2015
- URL
-
-
- Supplementary information
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- Request cross-referral to
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- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
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6
- Research group(s)
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-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- In this study, we designed a new formulation of HIPE (high internal phase emulsion) and showed for the first time that stem cells respond to how the factors they attach to are spaced around the struts of a porous 3D scaffold. This led to a one-step approach to control cell adhesion and differentiation without the need for coatings for use in regenerative medicine. The results were reported in many online science news outlets e.g. Phys.org, Science Daily, Stem Cells Freak. [https://phys.org/news/2012-12-biomaterial-sticky-stem-cells.html, https://www.sciencedaily.com/releases/2012/12/121210124212.htm, http://www.stemcellsfreak.com/2012/12/researchers-create-new-better-scaffold.html] and the work has been used by many groups in the field e.g.: doi.org/10.1016/j.actbio.2016.11.016 and doi.org/10.1073/pnas.1910166116.
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -