Combined flow-focus and self-assembly routes for the formation of lipid stabilized oil-shelled microbubbles
- Submitting institution
-
The University of Leeds
- Unit of assessment
- 12 - Engineering
- Output identifier
- ELEC-64
- Type
- D - Journal article
- DOI
-
10.1038/micronano.2017.87
- Title of journal
- Microsystems & Nanoengineering
- Article number
- 17087
- First page
- -
- Volume
- 4
- Issue
- -
- ISSN
- 2055-7434
- Open access status
- Compliant
- Month of publication
- February
- Year of publication
- 2018
- URL
-
-
- Supplementary information
-
https://static-content.springer.com/esm/art%3A10.1038%2Fmicronano.2017.87/MediaObjects/41378_2018_BFmicronano201787_MOESM9_ESM.pdf
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
-
5
- Research group(s)
-
-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- Microbubbles are currently used clinically for contrast imaging. This work demonstrates the first use of microfluidic techniques for the assembly of therapeutic microbubbles, in which the microbubble can also act as a vehicle for the delivery of toxic chemotherapy agents. Remote release by ultrasound then allows targeting of the therapy, providing an order-of-magnitude reduction in the exposure of the patient, compared to systemic injection. The patented work (US9802165B2) also overcomes the poor water solubility of many (~40%) new drugs.
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -
