Accurate Encoding and Decoding by Single Cells: Amplitude Versus Frequency Modulation
- Submitting institution
-
Goldsmiths' College
- Unit of assessment
- 11 - Computer Science and Informatics
- Output identifier
- 3455
- Type
- D - Journal article
- DOI
-
10.1371/journal.pcbi.1004222
- Title of journal
- PLOS Computational Biology
- Article number
- e1004222
- First page
- -
- Volume
- 11
- Issue
- 6
- ISSN
- 1553-734X
- Open access status
- Out of scope for open access requirements
- Month of publication
- June
- Year of publication
- 2015
- URL
-
http://research.gold.ac.uk/id/eprint/29292/
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
-
3
- Research group(s)
-
-
- Citation count
- 14
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- This work explores both theoretically and via numerical simulations the advantages and disadvantages of amplitude or frequency modulated signalling in gene regulation. Its importance lies in highlighting the more complex type of modulation of signalling that occur in cells at the fundamental level, which involves either membrane receptors binding/unbinding of ligand molecules or ion-channel opening/closing (or both) and therefore is more stochastic in nature as compared to classical radio signal modulation. A gap in understanding the role of this modulation has been highlighted by following cited research and confirms the importance of this line of research.
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -