Nanophotonic-Carbohydrate Lab-on-a-Microneedle for Rapid Detection of Human Cystatin C in Finger-Prick Blood
- Submitting institution
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University of Ulster
- Unit of assessment
- 12 - Engineering
- Output identifier
- 89515616
- Type
- D - Journal article
- DOI
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10.1021/acsnano.0c05074
- Title of journal
- ACS Nano
- Article number
- acsnano.0c05074
- First page
- 11939
- Volume
- 14
- Issue
- 9
- ISSN
- 1936-0851
- Open access status
- Not compliant
- Month of publication
- August
- Year of publication
- 2020
- URL
-
-
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
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6
- Research group(s)
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A - Healthcare Sensor Systems
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- Biomarker detection using whole blood was achieved via microneedles. These microneedles use LSPR sensing technology to detect the biomarker while demonstrating the concept of Filtration Extraction and Analysis (FEA) in a single device for the first time. Detection of cystatin C biomarker was successfully achieved within 30 seconds at clinically relevant concentrations related to Heart Failure. The work represents for the first time a hallmark in the state-of-art of miniaturised total analysis systems, for the rapid detection of disease biomarkers, with features including high sensitivity, selectivity, biocompatibility and disposability, all at low cost and is underpinning NIH-USA-2017-2561-1 Award
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -
