Group-based optimization of potent and cell-active inhibitors of the von Hippel-Lindau (VHL) E3 ubiquitin ligase : structure-activity relationships leading to the chemical probe (2S,4R)-1-((S)-2-(1-cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (VH298)
- Submitting institution
-
University of Dundee
- Unit of assessment
- 5 - Biological Sciences
- Output identifier
- 35890150
- Type
- D - Journal article
- DOI
-
10.1021/acs.jmedchem.7b00675
- Title of journal
- Journal of Medicinal Chemistry
- Article number
- -
- First page
- 599
- Volume
- 61
- Issue
- -
- ISSN
- 0022-2623
- Open access status
- Compliant
- Month of publication
- August
- Year of publication
- 2017
- URL
-
-
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
-
8
- Research group(s)
-
-
- Citation count
- 41
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- -
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -
