Electrochemical measurement of antibody‐antigen recognition biophysics: thermodynamics and kinetics of human chorionic gonadotropin (hCG) binding to redox-tagged antibodies
- Submitting institution
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The University of Hull
- Unit of assessment
- 12 - Engineering
- Output identifier
- 1398610
- Type
- D - Journal article
- DOI
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10.1016/j.jelechem.2018.02.062
- Title of journal
- Journal of Electroanalytical Chemistry
- Article number
- -
- First page
- 533
- Volume
- 819
- Issue
- -
- ISSN
- 1572-6657
- Open access status
- Compliant
- Month of publication
- March
- Year of publication
- 2018
- URL
-
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- Supplementary information
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- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
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6
- Research group(s)
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-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- This joint EPSRC-BBSRC funded research reveals the chemical biophysics behind a novel, reagent-free, antibody-based sensing platform that can provide rapid (15min), highly sensitive (~few ng/mL) antibody-antigen tests. The Covid-19 pandemic has highlighted the need to quickly develop and manufacture such sensors for biomarkers of disease. This research has demonstrated and validated the key requirements underpinning these techniques. It has been translated to detect cardiac Troponin T (a sensitive biomarker for myocardial infarction) and hormones (e.g. https://doi.org/10.1039/C8NJ02974A). A confidentiality agreement with The Technology Partnership is currently enabling commercialisation of this work to be explored (Giles.Sanders@ttp.com).
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -