A design protocol for tailoring ice-templated scaffold structure.
- Submitting institution
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University of Cambridge
- Unit of assessment
- 12 - Engineering
- Output identifier
- 7244
- Type
- D - Journal article
- DOI
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10.1098/rsif.2013.0958
- Title of journal
- J R Soc Interface
- Article number
- ARTN 20130958
- First page
- 20130958
- Volume
- 11
- Issue
- 92
- ISSN
- 1742-5662
- Open access status
- Out of scope for open access requirements
- Month of publication
- March
- Year of publication
- 2014
- URL
-
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- Supplementary information
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- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
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3
- Research group(s)
-
-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- This paper established for the first time that ice-templated collagen scaffold architecture may be designed and tailored though control of key thermal parameters during freeze drying. The senior authors secured follow-up funds with a GBP1.7 M EPSRC Joint Professorial Fellowship (EP/N019938/1) to develop the technology for nerve guidance, and cardiac and wound repair. The work led to the publication of a new hypothesis for the crystallographic mechanisms underpinning characteristic mesostructuring during ice sublimation (DOI:10.1103/PhysRevMaterials.2.040401 2018). The insights have significant implications in the development of optimised three dimensional environments for a variety of biological cell-types.
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -