Comprehensive in vitro and in vivo studies of novel melt-derived Nb-substituted 45S5 bioglass reveal its enhanced bioactive properties for bone healing
- Submitting institution
-
Aston University
- Unit of assessment
- 12 - Engineering
- Output identifier
- 26258087
- Type
- D - Journal article
- DOI
-
10.1038/s41598-018-31114-0
- Title of journal
- Scientific Reports
- Article number
- 12808
- First page
- -
- Volume
- 8
- Issue
- 1
- ISSN
- 2045-2322
- Open access status
- Deposit exception
- Month of publication
- August
- Year of publication
- 2018
- URL
-
-
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- Yes
- Number of additional authors
-
6
- Research group(s)
-
B - Aston Institute of Urban Technology and the Environment (ASTUTE)
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- This paper provided a rigorous in-vitro and in-vivo of novel niobium doped bioactive glasses. This paper is significant because the addition of niobium was found to significantly enhance its osteogenic capacity and increases the osteostimulation compared to Bioglass (the clinical gold standard).
This paper led to a major international collaboration, resulting in several key papers within the field (e.g. DOI: 10.1002/jbm.a.36826, DOI: 10.1002/jbm.b.34486). This paper stimulated significant interest in the dental community (e.g. DOI: 10.1007/s10971-020-05442-5, DOI:10.1016/j.dental.2020.09.010, DOI:10.1016/j.dental.2019.07.012).
This paper led to follow on funding through the Diamond Light Source to elucidate the structural role of niobium within these glasses (SP25639-2).
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -
