A Computational Tool for the Microstructure Optimization of a Polymeric Heart Valve Prosthesis.
- Submitting institution
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University of Cambridge
- Unit of assessment
- 12 - Engineering
- Output identifier
- 7498
- Type
- D - Journal article
- DOI
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10.1115/1.4033178
- Title of journal
- Journal of Biomechanical Engineering
- Article number
- ARTN 061001
- First page
- 061001
- Volume
- 138
- Issue
- 6
- ISSN
- 0148-0731
- Open access status
- Out of scope for open access requirements
- Month of publication
- April
- Year of publication
- 2016
- URL
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- Supplementary information
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- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
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6
- Research group(s)
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-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- This paper demonstrates, for the first time, optimisation of the design of anisotropic polymeric heart valves using finite element modelling; and shows that anisotropic polymers give superior performance to isotropic materials. The method described led to the design of both geometry and processing conditions of injection moulded prototype polymeric valves, subsequently shown to comfortably exceed ISO standards for in vitro testing; and which are currently being tested in vivo in sheep (under BHF Special Project Grant SP/15/5/31548). It has also led to a method of lifetime prediction for polymeric valves, which greatly shortens the design cycle of new prototypes.
- Author contribution statement
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- Non-English
- No
- English abstract
- -