The Role of Parvalbumin-positive Interneurons in Auditory Steady-State Response Deficits in Schizophrenia
- Submitting institution
-
University of Hertfordshire
- Unit of assessment
- 11 - Computer Science and Informatics
- Output identifier
- 20233648
- Type
- D - Journal article
- DOI
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10.1038/s41598-019-53682-5
- Title of journal
- Scientific Reports
- Article number
- 18525
- First page
- -
- Volume
- 9
- Issue
- 1
- ISSN
- 2045-2322
- Open access status
- Compliant
- Month of publication
- December
- Year of publication
- 2019
- URL
-
-
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
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2
- Research group(s)
-
-
- Citation count
- 1
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- This work is part of an ongoing collaboration with a mathematician at the Free University of Berlin (Dr Metzner) and a psychiatrist at the University of Lübeck, Germany (Prof Zurowski). The article describes a computational model of cellular alterations in schizophrenia patients. Computer simulations and analyses of the model suggest a novel mechanism that could underlie some symptoms of schizophrenia, providing a first step towards developing a new therapy of schizophrenia. The work has inspired follow-on studies leading to two journal articles under review.
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -