Contributions to Drug Resistance in Glioblastoma Derived from Malignant Cells in the Sub-Ependymal Zone
- Submitting institution
-
University of Brighton
- Unit of assessment
- 11 - Computer Science and Informatics
- Output identifier
- 7122306
- Type
- D - Journal article
- DOI
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10.1158/0008-5472.CAN-13-3131
- Title of journal
- Cancer Research
- Article number
- -
- First page
- 194
- Volume
- 75
- Issue
- 1
- ISSN
- 0008-5472
- Open access status
- Out of scope for open access requirements
- Month of publication
- November
- Year of publication
- 2014
- URL
-
-
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- Yes
- Number of additional authors
-
14
- Research group(s)
-
-
- Citation count
- 33
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- Glioblastoma is the most common and aggressive adult brain tumour with failing therapeutical treatments. This paper is significant because (a) it identified the existence of fluorescent tissue in the sub-ependymal zone, (b) revealed that the subventricular zone harbours malignant cells with tumour-initiating capacity and, (c) proved resistance to supramaximal chemotherapy doses along these two groups of cells with differential patterns of drug response in the same tumour. This led to novel insights into glioblastoma growth dynamics and treatment resistance and inspired more research on this topic including Ellis et al., (Front. Oncol. 2015) and Salazar-Ramiro et al., (Front. Immunol. 2016).
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -
