An endogenous nanomineral chaperones luminal antigen and peptidoglycan to intestinal immune cells
- Submitting institution
-
The University of Leeds
- Unit of assessment
- 12 - Engineering
- Output identifier
- CHEM-20
- Type
- D - Journal article
- DOI
-
10.1038/nnano.2015.19
- Title of journal
- Nature Nanotechnology
- Article number
- -
- First page
- 361
- Volume
- 10
- Issue
- -
- ISSN
- 1748-3387
- Open access status
- Out of scope for open access requirements
- Month of publication
- March
- Year of publication
- 2015
- URL
-
-
- Supplementary information
-
https://www.nature.com/articles/nnano.2015.19#Sec21
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- Yes
- Number of additional authors
-
24
- Research group(s)
-
-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- This paper identifies a new endogenous nanoparticle pathway which may help the immune system to develop tolerance to food and bacteria. Further investigation has shown that this pathway is indeed altered in intestinal tissue from patients with Crohn’s disease (doi:10.1038/srep26747). The electron microscopy methods developed at Leeds for this work continues with characterisation of bio-therapeutic-loaded calcium phosphate nanoparticles for the treatment of Crohn’s (using equipment access funded via grant EP/R02863X/1) and has been recently adapted to assess the gut’s inflammatory response to food grade TiO2 particles (doi:10.1002/smll.202000486) using microscopy instrumentation funded by EPSRC grant EP/P00122X/1.
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -
