A novel radiotracer to image glycogen metabolism in tumors by positron emission tomography
- Submitting institution
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King's College London
- Unit of assessment
- 12 - Engineering
- Output identifier
- 103181695
- Type
- D - Journal article
- DOI
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10.1158/0008-5472.CAN-13-2768
- Title of journal
- Cancer Research
- Article number
- -
- First page
- 1319
- Volume
- 74
- Issue
- 5
- ISSN
- 0008-5472
- Open access status
- Out of scope for open access requirements
- Month of publication
- March
- Year of publication
- 2014
- URL
-
-
- Supplementary information
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-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- Yes
- Number of additional authors
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9
- Research group(s)
-
-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- Glycogen is the body’s primary glucose storage molecule. It has been shown recently that drug-resistant cancer selectively increase glycogen stores and exit from the cell cycle. Here, we created the first non-invasive glycogen PET tracer. We showed that glycogen imaging can be used for precise tumour diagnosis and that we could identify non-dividing ‘quiescent’ cells that were innately drug resistant. The early detection of drug resistance will enable the selection of alternative treatment combinations that will result in improved outcomes in cancer. This work has directly led to follow-on MRC funding (£3.8m, MR/N020782/1) to support further development of this tracer.
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -