Dietary Docosahexaenoic Acid Reduces Oscillatory Wall Shear Stress, Atherosclerosis, and Hypertension, Most Likely Mediated via an IL‐1–Mediated Mechanism
- Submitting institution
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The University of Sheffield
- Unit of assessment
- 11 - Computer Science and Informatics
- Output identifier
- 2505
- Type
- D - Journal article
- DOI
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10.1161/JAHA.118.008757
- Title of journal
- Journal of the American Heart Association
- Article number
- e008757
- First page
- -
- Volume
- 7
- Issue
- 13
- ISSN
- 2047-9980
- Open access status
- Compliant
- Month of publication
- June
- Year of publication
- 2018
- URL
-
-
- Supplementary information
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- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
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9
- Research group(s)
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E - OAK
- Citation count
- 11
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- The first paper to perform Computational Fluid Dynamics analysis of blood flow in the fine aortic vessels of mice. Our model provides a mechanistic explanation to recent nutritional studies suggesting that docosahexaenoic acid, present in fish, has anti-inflammatory effects. This significant development opens the potential of low-cost dietary interventions instead of costly polypharmacy solutions. Reducing inflammation is expected to delay the onset of multimorbidity (co-occurrence of multiple chronic diseases), a key problem for our aging society and an NHS priority (https://www.england.nhs.uk/publication/next-steps-on-the-nhs-five-year-forward-view/). Our findings are used by groups in China, Poland, the UK and the USA (doi.org/10.1186/s12986-019-0359-2, doi.org/10.1124/pr.118.017178, doi.org/10.1161/HYPERTENSIONAHA.119.13642, doi.org/10.1161/JAHA.120.016099).
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -