A simulation model of periarterial clearance of amyloid-beta from the brain
- Submitting institution
-
University of Southampton
- Unit of assessment
- 12 - Engineering
- Output identifier
- 21221287
- Type
- D - Journal article
- DOI
-
10.3389/fnagi.2016.00018
- Title of journal
- Frontiers in Aging Neuroscience
- Article number
- 18
- First page
- -
- Volume
- 8
- Issue
- -
- ISSN
- 1663-4365
- Open access status
- Out of scope for open access requirements
- Month of publication
- February
- Year of publication
- 2016
- URL
-
-
- Supplementary information
-
https://eprints.soton.ac.uk/386692/
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
-
6
- Research group(s)
-
-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- As the most common form of dementia, Alzheimer’s disease (AD) impacts a person’s ability to think and function. Currently, the progression of AD is not well understood. An active research area is the role of amyloid-β (Aβ) and the transportation of Aβ in the brain in AD.
In this paper, a computer based methodology is development to model the process of periarterial drainage of Aβ in the brain and it is found that periarterial drainage is very rapid compared with diffusion. This is significant in the context of failure of periarterial drainage as a mechanism underlying the pathogenesis of AD.
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -