64CuCTS : a promising radiopharmaceutical for the identification of low grade cardiac hypoxia by PET
- Submitting institution
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King's College London
- Unit of assessment
- 12 - Engineering
- Output identifier
- 97643069
- Type
- D - Journal article
- DOI
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10.2967/jnumed.114.148353
- Title of journal
- Journal of Nuclear Medicine
- Article number
- 56
- First page
- 921
- Volume
- 56
- Issue
- 6
- ISSN
- 0161-5505
- Open access status
- Out of scope for open access requirements
- Month of publication
- April
- Year of publication
- 2015
- URL
-
-
- Supplementary information
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-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- Yes
- Number of additional authors
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6
- Research group(s)
-
-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- We have invented a family of hypoxia-selective 64Cu-labelled radiotracers for detecting ischaemic cardiovascular disease by PET. By titrating radiotracer uptake against cardiac oxygenation, we demonstrate that our compound [64Cu]-CuATS is more sensitive to hypoxia than any previous agents, and use 31P NMR spectroscopy to show that tracer accumulation occurs exactly at the hypoxic threshold where the heart becomes unable to maintain normal aerobic metabolism, and would benefit most from surgical/pharmacologic intervention. This unique approach secured BHF project grant PG/16/43/32141, was central to a new collaboration with Oxford (EPSRC Program EP/S019901/1) and underpinned EP/S032789/1 to progress new radiotracers to clinical translation.
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -
