A correlative spatiotemporal microscale study of calcium phosphate formation and transformation within an alginate hydrogel matrix
- Submitting institution
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The University of Birmingham
- Unit of assessment
- 12 - Engineering
- Output identifier
- 42818608
- Type
- D - Journal article
- DOI
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10.1016/j.actbio.2016.08.041
- Title of journal
- Acta Biomaterialia
- Article number
- -
- First page
- 254
- Volume
- 44
- Issue
- -
- ISSN
- 1742-7061
- Open access status
- Deposit exception
- Month of publication
- August
- Year of publication
- 2016
- URL
-
-
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- Yes
- Number of additional authors
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5
- Research group(s)
-
-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- Calcium phosphate (CaP) mineralisation is complex; both formation kinetics and stabilities of different mineral phases control the outcome. We developed a novel experimental platform that enabled the application of a wide range of correlative characterisation techniques to study CaP mineralisation. Previously unattainable spatiotemporal resolution was achieved. This technique enables detailed investigation of mineralisation and aids future rational design of biomaterials for tissue engineering. It was showcased in an international invited talk (2016 COST meeting, Czech Republic) and is now being applied to develop in-vitro models of bone, in collaboration with leading scientists from the Universities of Oslo and Maastricht.
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -
