Optimisation of a series of bivalent triazolopyridazine based bromodomain and extraterminal inhibitors: the discovery of (3R)-4-[2-[4-[1-(3-methoxy-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-4-piperidyl]phenoxy]ethyl]-1,3-dimethyl-piperazin-2-one (AZD5153)
- Submitting institution
-
University of Newcastle upon Tyne
- Unit of assessment
- 8 - Chemistry
- Output identifier
- 227336-199834-1290
- Type
- D - Journal article
- DOI
-
10.1021/acs.jmedchem.6b00070
- Title of journal
- Journal of Medicinal Chemistry
- Article number
- -
- First page
- 7801
- Volume
- 59
- Issue
- 17
- ISSN
- 0022-2623
- Open access status
- Compliant
- Month of publication
- August
- Year of publication
- 2016
- URL
-
http://dx.doi.org/10.1021/acs.jmedchem.6b00070
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
-
23
- Research group(s)
-
-
- Citation count
- 35
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- -
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -