Etidronate rescues cognitive deficits through improving synaptic transmission and suppressing apoptosis in 2-vessel occlusion model rats
- Submitting institution
-
University of Hertfordshire
- Unit of assessment
- 12 - Engineering
- Output identifier
- 13466117
- Type
- D - Journal article
- DOI
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10.1111/jnc.13904
- Title of journal
- Journal of Neurochemistry
- Article number
- -
- First page
- 476
- Volume
- 140
- Issue
- 3
- ISSN
- 0022-3042
- Open access status
- Compliant
- Month of publication
- January
- Year of publication
- 2017
- URL
-
-
- Supplementary information
-
-
- Request cross-referral to
- 5 - Biological Sciences
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- Yes
- Number of additional authors
-
5
- Research group(s)
-
-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- Bisphosphonate (i.e. Etidronate) is highly compatible with hydroxyapatite, it has long been used to treat common bone disease including bone cancers. An increasing amount of medical evidence indicates elderly patients suffering from bone disorders also appear to develop neurological complications (i.e. Alzheimer & dementia). This research, supported by the National Natural Science Foundation of China (81571804), provided the first observed scientific evidence of neural protective effects of Etidronate via rat models. The project is now progressing to the next phase to test newly developed bisphosphonates for improved bioactivity and high potency as a dual-therapeutic agent for prevention of cognitive impairment.
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -