Development of two-photon polymerised scaffolds for optical interrogation and neurite guidance of human iPSC-derived cortical neuronal networks
- Submitting institution
-
Aston University
- Unit of assessment
- 12 - Engineering
- Output identifier
- 44437910
- Type
- D - Journal article
- DOI
-
10.1039/c9lc01209e
- Title of journal
- Lab on a Chip
- Article number
- -
- First page
- 1792
- Volume
- 20
- Issue
- 10
- ISSN
- 1473-0197
- Open access status
- Compliant
- Month of publication
- April
- Year of publication
- 2020
- URL
-
-
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- Yes
- Number of additional authors
-
14
- Research group(s)
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A - Aston Institute of Photonic Technologies (AIPT)
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- This paper reports interdisciplinary research resulting from the EU FET MESO-BRAIN project with partners from Spain, Germany and company Axol Bioscience Ltd. (UK). The paper is the first demonstration of a feasibility of using laser 2-photon polymerisation to fabricate scaffolds with tailored topographies providing an effective method of producing defined in vitro human induced pluripotent stem cells for bio-neural networks. Two-photon polymerisation enables precise microfabrication of three-dimensional structures and the optical interrogation of individual cells. Paper led to two EU H2020 MSCA Fellowship projects MultiBioScan and MIDLIFT, and contributed substantially to the recently awarded H2020 FET Neu-Chip project.
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -
