Structurally graduated collagen scaffolds applied to the ex vivo generation of platelets from human pluripotent stem cell-derived megakaryocytes: Enhancing production and purity
- Submitting institution
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The University of Leicester
- Unit of assessment
- 12 - Engineering
- Output identifier
- 1549
- Type
- D - Journal article
- DOI
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10.1016/j.biomaterials.2018.08.019
- Title of journal
- Biomaterials
- Article number
- -
- First page
- 135
- Volume
- 182
- Issue
- -
- ISSN
- 0142-9612
- Open access status
- Technical exception
- Month of publication
- August
- Year of publication
- 2018
- URL
-
-
- Supplementary information
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https://doi.org/10.1016/j.biomaterials.2018.08.019
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
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13
- Research group(s)
-
-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- This work provided a significant step forward in the development of a clinically relevant system for the ex vivo generation of blood platelets. Taking inspiration from the native bone marrow niche, the generation of functional blood platelets was demonstrated from a renewable source of banked stem cells, using a modular bioreactor design and biomaterials capable of being mass produced. A range of follow up funding has been awarded to Ghevaert, including a first phase feasibility study funded by the DSTL (totalling £350k) investigating the transition of in vitro platelet production to GMP.
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -