Microscopic Investigation of the Combined Use of Antibiotics and Biosurfactants on Methicillin Resistant Staphylococcus aureus
- Submitting institution
-
University of Ulster
- Unit of assessment
- 12 - Engineering
- Output identifier
- 85980196
- Type
- D - Journal article
- DOI
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10.3389/fmicb.2020.01477
- Title of journal
- Frontiers in Microbiology
- Article number
- 1477
- First page
- 1
- Volume
- 0
- Issue
- 0
- ISSN
- 1664-302X
- Open access status
- Compliant
- Month of publication
- July
- Year of publication
- 2020
- URL
-
-
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
-
7
- Research group(s)
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E - Advanced Manufacturing
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- With no new antibiotics developed since the 1980s, multidrug resistant WHO-priority pathogens, such as MRSA can potentially endanger patients undergoing relatively routine surgery such as cesarean sections and hip replacements. New approaches combining new molecules with antibiotics involve multiple interactions which limit the usefulness of traditional biological assays, hence, the novel use here of AFM microscopy and SEM microscopy to study the morphological changes occurring to MRSA when exposed to a combination of antibiotics and biosurfactants. The study suggests that a small concentration of the biosurfactant sophorolipid has the potential to restore the efficacy of tetracycline antibiotics against MRSA.
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -