Effects of Hypothermia for Perinatal Asphyxia on Childhood Outcomes
- Submitting institution
-
King's College London
- Unit of assessment
- 12 - Engineering
- Output identifier
- 78571163
- Type
- D - Journal article
- DOI
-
10.1056/NEJMoa1315788
- Title of journal
- New England Journal of Medicine
- Article number
- -
- First page
- 140
- Volume
- 371
- Issue
- 2
- ISSN
- 0028-4793
- Open access status
- Out of scope for open access requirements
- Month of publication
- July
- Year of publication
- 2014
- URL
-
-
- Supplementary information
-
-
- Request cross-referral to
- 1 - Clinical Medicine
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
-
16
- Research group(s)
-
-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- This study [NCT01092637] is the definitive assessment of therapeutic hypothermia, a novel technology which is the only treatment proven to reduce the severe damage caused by birth asphyxia. It was discovered and developed by our group and collaborators, from initial animal experiments using complex MR 31P and 1H spectroscopy, through phase 1-4 trials also involving MRI. This study followed the TOBY trial [NCT00147030], which was the second and largest of our phase 3 trials, and showed that treatment doubles the chance of normal long-term survival. It is now routine treatment across the world, rescuing many lives and reducing healthcare costs.
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -