Characterisation of Liposome-Loaded Microbubble Populations for Subharmonic Imaging
- Submitting institution
-
The University of Leeds
- Unit of assessment
- 12 - Engineering
- Output identifier
- ELEC-43
- Type
- D - Journal article
- DOI
-
10.1016/j.ultrasmedbio.2016.09.011
- Title of journal
- Ultrasound in Medicine and Biology
- Article number
- -
- First page
- 346
- Volume
- 43
- Issue
- 1
- ISSN
- 0301-5629
- Open access status
- Compliant
- Month of publication
- October
- Year of publication
- 2016
- URL
-
https://doi.org/10.1016/j.ultrasmedbio.2016.09.011
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
-
5
- Research group(s)
-
-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- Theranostic microbubbles offer great potential for future cancer treatments, owing to their low systemic toxicity and the ability to achieve high placement precision. This study was the first demonstration that unique subharmonic acoustic emissions are generated from liposome-loaded microbubbles (at significantly lower acoustic pressures than observed for standard ‘bare’ microbubble populations). This enables liposome-loaded microbubbles both to be used for molecular-targeted imaging as well as drug delivery. This dual functionality is undergoing testing by the Medicines Discovery Catapult (email on request) for translation to the first in-human use, and is being developed further through additional ESPRC funding (EP/P023266/1, £835k).
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -
