The role of differential VE-cadherin dynamics in cell rearrangement during angiogenesis
- Submitting institution
-
King's College London
- Unit of assessment
- 11 - Computer Science and Informatics
- Output identifier
- 111166701
- Type
- D - Journal article
- DOI
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10.1038/ncb2926
- Title of journal
- Nature Cell Biology
- Article number
- -
- First page
- 309
- Volume
- 16
- Issue
- 4
- ISSN
- 1465-7392
- Open access status
- Out of scope for open access requirements
- Month of publication
- March
- Year of publication
- 2014
- URL
-
-
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- Yes
- Number of additional authors
-
13
- Research group(s)
-
-
- Citation count
- 191
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- Predictive computational model validated experimentally in vivo changed perspective of blood vessel adhesion from vessel scale to individual cell scale. Novelty and contribution highlighted by Choi EMBO J 2014 & Dejana, Nature Cell Bio 2014. No.1 most downloaded paper by NAVBO community 2014. Request to integrate model with permeability experiments generated collaborative funding ~£5M (KAW foundation) https://www.uu.se/en/news/article/?id=5456&typ=artikel and a satellite lab at Uppsala University. The associated computational image analysis tool https://github.com/Bentley-Cellular-Adaptive-Behaviour-Lab/VE-cadherin-Patch-Classification has been requested by 20+ labs worldwide resulting in numerous publications, e.g. Kur, eLife 2016, Cruys, Nature Comms 2016. Invited talk at GRC CC & Adhesion 2017 https://www.grc.org/cell-contact-and-adhesionconference/ 2017.
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -