A patient tumour-on-a-chip system for personalised investigation of radiotherapy based treatment regimens
- Submitting institution
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The University of Hull
- Unit of assessment
- 12 - Engineering
- Output identifier
- 1624416
- Type
- D - Journal article
- DOI
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10.1038/s41598-019-42745-2
- Title of journal
- Scientific reports
- Article number
- 6327
- First page
- -
- Volume
- 9
- Issue
- 1
- ISSN
- 2045-2322
- Open access status
- Compliant
- Month of publication
- April
- Year of publication
- 2019
- URL
-
-
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
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8
- Research group(s)
-
-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- In this work, a novel robust and easy to use tumour-on-a-chip platform has been developed which can maintain head and neck biopsy tissue to allow personalised irradiation testing. This proof-of-principle study demonstrated that tissue viability could be maintained for up to 68 hours, allowing tumour-specific doses to be investigated prior to patient treatment. This work has already been applied to other malignancies, e.g. NC3Rs funding (NC/T001232/1: Utilising tissue-on-a-chip technology as an ex vivo model of breast cancer metastatic colonisation) to investigate breast cancer cells.
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -