Dynamic patterns of cortical expansion during folding of the preterm human brain
- Submitting institution
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King's College London
- Unit of assessment
- 12 - Engineering
- Output identifier
- 97970238
- Type
- D - Journal article
- DOI
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10.1073/pnas.1715451115
- Title of journal
- Proceedings of the National Academy of Sciences of the United States of America
- Article number
- -
- First page
- 3156
- Volume
- 115
- Issue
- 12
- ISSN
- 1091-6490
- Open access status
- Compliant
- Month of publication
- March
- Year of publication
- 2018
- URL
-
-
- Supplementary information
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-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- Yes
- Number of additional authors
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12
- Research group(s)
-
-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- Preterm birth is known to be a strong risk-factor for neurological and psychological impairment later in life. However, the mechanisms with which it impacts brain-development remain unclear. This study reflects the first imaging-based, biomechanical model of fetal brain-growth. It is based on our open-source, brain-matching tool MSM (https://doi.org/10.1016/j.neuroimage.2014.05.069, https://github.com/ecr05/MSM_HOCR) and allows deviations from normal development to be detected for individual babies, for the first time. In future, this will support mechanistic studies of how genetic disorders impact cognition (e.g. https://doi.org/10.1038/s41390-018-0208-4). It has led to a new industry-sponsored PhD project (https://bit.ly/3717pYA) modelling cortical-growth and novel collaborations modelling brain evolution (https://doi.org/10.1101/645234).
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -