A compartmental CFD-PBM model of high shear wet granulation
- Submitting institution
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The University of Sheffield
- Unit of assessment
- 12 - Engineering
- Output identifier
- 2667
- Type
- D - Journal article
- DOI
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10.1002/aic.15401
- Title of journal
- AIChE Journal
- Article number
- -
- First page
- 438
- Volume
- 63
- Issue
- 2
- ISSN
- 0001-1541
- Open access status
- Compliant
- Month of publication
- July
- Year of publication
- 2016
- URL
-
-
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
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5
- Research group(s)
-
-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- Modelling of any industrial fine particle process inevitably requires multi-scale approaches and is particularly challenging when both motion and multiple-property kinetics must be considered. This paper, involving two Universities and two branches of a major pharmaceutical company in Sweden and the UK, combines CFD and Monte Carlo modelling. The novel methodology presented here is tested at multiple length scales for motion, particle size and liquid distribution. The coupling of these phenomena means that no model for prediction of product quality, (e.g. drug distribution in a pharmaceutical formulation), can be classed as rigorous without going to the lengths reported here.
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -