Computerized tomography systems and methods
- Submitting institution
-
University of Lincoln
- Unit of assessment
- 9 - Physics
- Output identifier
- 34951
- Type
- F - Patent/ published patent application
- Patent registration number
- US20170112457
- Month
- July
- Year
- 2018
- URL
-
http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=10028712.PN.&OS=PN/10028712&RS=PN/10028712
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
-
0
- Research group(s)
-
-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- Awarded US patent, and European companion (EP 3 151 918 B1), describes a solid-state proton imaging system for reducing range uncertainties in Proton Beam Therapy. Major uncertainty is the translation of Hounsfield Units into relative proton stopping power using conventional x-ray CT planning. Initial experiments showed satisfactory signals from single protons could be obtained in CMOS sensors (G Poludniowski et al 2014 Phys. Med. Biol. 59 2569). Support from a Wellcome Grant, PRaVDA, allowed the design, construction and use of a novel instrument. All work supported by detailed Monte Carlo modelling (eg, M. Esposito et al 2017 JINST 12 P03028). This modelling work was awarded the IET Prize for Innovation: Model-based Engineering, 2016. All sensors have been fully characterised in terms of sensitivity, noise, radiation damage, etc, (eg, M. Esposito et al, 2018 JINST 13 P11017). Innovative elements of the instrument include (a) multiple silicon strip sensor proton trackers with a count rate of 3 x 108 events/s (J T Taylor et al, 2016, Nucl. Instrum. Methods Phys. Res. A831, 362-366), and (b) 23 silicon sensor layer range telescope for recoding the residual energy of individual protons (T. Price et al 2015 JINST 10 P05013). The instrument was used at the iThemba LABS, South Africa and produced the most accurate directly-recorded proton stopping powers (M Esposito et al, 2016, Physica Medica, 55, 149-154) and the first demonstration of a scattering power proton CT (J T Taylor et al, Medical physics, 43, 6129-6136). The team was awarded a £3.2m EPSRC grant (EP/R023220/1) in 2018 to develop system for the NHS Christie Proton Beam Therapy Centre. See related ICS. N M Allinson is an author on all referenced papers.
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -