Dynamic brain network states in human generalized spike-wave discharges
- Submitting institution
-
King's College London
- Unit of assessment
- 12 - Engineering
- Output identifier
- 101129103
- Type
- D - Journal article
- DOI
-
10.1093/brain/awy223
- Title of journal
- Brain
- Article number
- -
- First page
- 2981
- Volume
- 141
- Issue
- 10
- ISSN
- 0006-8950
- Open access status
- Compliant
- Month of publication
- August
- Year of publication
- 2018
- URL
-
-
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
-
6
- Research group(s)
-
-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- Generalised epilepsy is thought to arise from large-scale brain network abnormalities, but when patient’s seizures occur and how to treat them is not fully understood. We provide first evidence in humans of a predisposing brain state using novel analysis of combined Electroencephalography(EEG) and functional Magnetic Resonance Imaging data where the phase relationship between brain regions was used (rather than amplitude based correlation) and interrogated before and during epileptic events. This has already led to further grant funding (Epilepsy Research UK, PGE1802, https://epilepsyresearch.org.uk/research_portfolio/electrical-stimulation-as-a-potential-treatment-for-juvenile-myoclonic-epilepsy/) to pilot electrical stimulation treatment based on this finding, to provide data to plan and power clinical trials.
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -