Cardiac Hypoxia Imaging : Second Generation Analogues of 64Cu-ATSM
- Submitting institution
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King's College London
- Unit of assessment
- 12 - Engineering
- Output identifier
- 97643070
- Type
- D - Journal article
- DOI
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10.2967/jnumed.113.129015
- Title of journal
- Journal of Nuclear Medicine
- Article number
- -
- First page
- 488
- Volume
- 55
- Issue
- 3
- ISSN
- 0161-5505
- Open access status
- Out of scope for open access requirements
- Month of publication
- March
- Year of publication
- 2014
- URL
-
-
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- Yes
- Number of additional authors
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8
- Research group(s)
-
-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- We developed a new approach for screening and characterising novel radiopharmaceuticals using beating isolated perfused rat hearts. It has advantages over cell culture in terms of speed, physiological relevance, and pharmacokinetic profiling, and and offers more experimental control than in vivo models. We have also constructed a parallel apparatus within a 9.4T NMR magnet for biological contextualisation and validation. Here, we use the approach to identify two new hypoxia-targeting complexes which surpass the current gold standards [64Cu]-CuATSM and [18F]-FMISO. This approach was core to several subsequent grants developing and validating novel radiotracers (BHF PG/16/43/32141 and EPSRC Programmes EP/S019901/1 and EP/S032789/1).
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -