A de novo Self‐Assembling Peptide Hydrogel Biosensor with Covalently Immobilised DNA‐Recognising Motifs
- Submitting institution
-
The University of Manchester
- Unit of assessment
- 12 - Engineering
- Output identifier
- 51470313
- Type
- D - Journal article
- DOI
-
10.1039/C6CC01433J
- Title of journal
- Chemical Communications
- Article number
- -
- First page
- 6697
- Volume
- 52
- Issue
- 40
- ISSN
- 1359-7345
- Open access status
- Compliant
- Month of publication
- April
- Year of publication
- 2016
- URL
-
-
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- Yes
- Number of additional authors
-
3
- Research group(s)
-
C - CEAS
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- A brand new strategy for immobilizing DNA recognition motifs within 3-dimensional fibrillar peptide hydrogels is introduced to open up a new generation of nano-biosensors that gives reliable and robust detection of DNA sequences. This manuscript outlines the first example of such self-assembling peptide-oligonucleotide functionalized 3D hydrogels which is conceptually simple and offers a biologically relevant environment for the detection of DNA. Previous attempts to incorporate DNA aptamers have not been successful. This strategy has opened up a new field and various groups are developing these materials into diagnostic and prognostic tools in human pathophysiology.
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -
