Synthesis of Caffeine/Maleic Acid Co-crystal by Ultrasound-assisted Slurry Co-crystallization
- Submitting institution
-
The University of Bradford
- Unit of assessment
- 12 - Engineering
- Output identifier
- 63
- Type
- D - Journal article
- DOI
-
10.1016/j.xphs.2016.09.009
- Title of journal
- Journal of Pharmaceutical Sciences
- Article number
- -
- First page
- 66
- Volume
- 106
- Issue
- 1
- ISSN
- 0022-3549
- Open access status
- Compliant
- Month of publication
- -
- Year of publication
- 2016
- URL
-
https://jpharmsci.org/article/S0022-3549(16)41703-X/fulltext
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
-
4
- Research group(s)
-
-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- Cocrystals offer the possibility of improving the properties of drugs, such as solubility, by combining them with pharmaceutically accepted co-formers to make new crystal structures. Previously it was only possible to produce cocrystals using laboratory scale solvent-based methods. This new process, based upon the application of ultrasonic energy to accelerate co-crystallisation in a water-based slurry was developed at Bradford as part of an interdisciplinary PhD, under the umbrella of EPSRC project EP/J003360/1. The findings of the research offer the possibility of a scalable green manufacturing process to enable production of this new class of pharmaceutical materials.
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -
