An evolutionarily conserved function of polycomb silences the MHC Class I antigen presentation pathway and enables immune evasion in cancer
- Submitting institution
-
University of Southampton
- Unit of assessment
- 5 - Biological Sciences
- Output identifier
- 64354418
- Type
- D - Journal article
- DOI
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10.1016/j.ccell.2019.08.008
- Title of journal
- Cancer Cell
- Article number
- -
- First page
- 385
- Volume
- 36
- Issue
- 4
- ISSN
- 1535-6108
- Open access status
- Compliant
- Month of publication
- September
- Year of publication
- 2019
- URL
-
-
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
-
27
- Research group(s)
-
-
- Citation count
- 68
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- -
- Author contribution statement
- Siddle - In this paper we contributed experiments to assess B2-microglobulin expression on Devil Facial Tumour cells after inhibition of polycomb complexes, allowing comparison to other cell lines and contributing evidence of evolutionary conservation in mechanism. The antibodies to perform these experiments were developed in the Siddle lab. I also contributed to editing of the manuscript.
- Non-English
- No
- English abstract
- -