Converging parallel plate flow chambers for studies on the effect of the spatial gradient of wall shear stress on endothelial cells
- Submitting institution
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Birmingham City University
- Unit of assessment
- 12 - Engineering
- Output identifier
- 12Z_OP_D0032
- Type
- D - Journal article
- DOI
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10.4236/jbm.2014.22008
- Title of journal
- Journal of Biosciences and Medicines
- Article number
- -
- First page
- 50
- Volume
- 2014
- Issue
- 2
- ISSN
- 2327-5081
- Open access status
- Out of scope for open access requirements
- Month of publication
- -
- Year of publication
- 2014
- URL
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https://file.scirp.org/Html/45465.html
- Supplementary information
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-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
-
-
- Research group(s)
-
-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- Many in vitro studies focus on effects of wall shear stress (WSS) and wall shear stress gradient (WSSG) on endothelial cells, which are linked to the initiation and progression of atherosclerosis in the arterial system. Limitation in available flow chambers with a constant WSSG in the testing region makes it difficult to quantify cellular responses to WSSG. In this study, a converging parallel plate flow chamber (PPFC) is proposed that provides a controlled flow environment with a constant WSSG. This proposed converging flow chamber enables an easy and direct quantification of WSS and WSSG on cells cultured in the chamber.
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -