Activation of human Natural Killer cells by graphene oxide-templated antibody nanoclusters
- Submitting institution
-
Imperial College of Science, Technology and Medicine
- Unit of assessment
- 12 - Engineering
- Output identifier
- 401
- Type
- D - Journal article
- DOI
-
10.1021/acs.nanolett.8b01089
- Title of journal
- Nano Letters: a journal dedicated to nanoscience and nanotechnology
- Article number
- -
- First page
- 3282
- Volume
- 18
- Issue
- 5
- ISSN
- 1530-6984
- Open access status
- Compliant
- Month of publication
- April
- Year of publication
- 2018
- URL
-
-
- Supplementary information
-
10.1021/acs.nanolett.8b01089
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
-
3
- Research group(s)
-
-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- We show enhanced function of monoclonal antibodies for activating immune (NK) cells, a key technology in immunotherapy, if they are applied as nanoclusters, templated by graphene oxide nanoflakes. This generates a new soluble nanoreagent that activates cells without binding to a target surface. Citations include from China, Korea, Israel, France, USA; tweets from at least 6 countries (http://www.altmetric.com/details/38418067). The work resulted in an invited talk at international conference (http://www.weizmann.ac.il/conferences/smc2020/s); an invited Engineering Faculty Seminar at Kiel University (2018); a CRUK-EPSRC funding application currently in the final round.
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -
