Attenuation correction synthesis for hybrid PET-MR scanners : Application to brain studies
- Submitting institution
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King's College London
- Unit of assessment
- 12 - Engineering
- Output identifier
- 98364520
- Type
- D - Journal article
- DOI
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10.1109/TMI.2014.2340135
- Title of journal
- IEEE Transactions on Medical Imaging
- Article number
- 6858020
- First page
- 2332
- Volume
- 33
- Issue
- 12
- ISSN
- 0278-0062
- Open access status
- Out of scope for open access requirements
- Month of publication
- July
- Year of publication
- 2014
- URL
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- Supplementary information
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- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
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14
- Research group(s)
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-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- Originality: brain studies using PET-MR have been hampered by major quantification errors due to poor attenuation correction. We introduce the first method to provide equivalent quantification of radioactivity concentration measured by a standard PET-CT system without acquiring a CT. Significance: enabled the development of major brain studies using PET-MR (Insight46: https://doi.org/10.1186/s12883-017-0846-x). This technique is now a gold standard and has been integrated into most PET-MR studies within the Dementias Platform UK (DPUK MR-PET Partnership, MR/N025792/1) and internationally (AmyPAD, EU/IMI2-115952). Rigour: Tested against 11 published techniques, including two vendor-implemented solutions on 359 subjects and 3 radiotracers (https://doi.org/10.1016/j.neuroimage.2016.12.010), performing the most accurately.
- Author contribution statement
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- Non-English
- No
- English abstract
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