Selection of endurance capabilities and the trade-off between pressure and volume in the evolution of the human heart
- Submitting institution
-
Cardiff Metropolitan University / Prifysgol Metropolitan Caerdydd
- Unit of assessment
- 24 - Sport and Exercise Sciences, Leisure and Tourism
- Output identifier
- CSS546
- Type
- D - Journal article
- DOI
-
10.1073/pnas.1906902116
- Title of journal
- Proceedings of the National Academy of Sciences
- Article number
- -
- First page
- 19905
- Volume
- 116
- Issue
- 40
- ISSN
- 1091-6490
- Open access status
- Compliant
- Month of publication
- September
- Year of publication
- 2019
- URL
-
-
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
-
11
- Research group(s)
-
-
- Proposed double-weighted
- Yes
- Double-weighted statement
- This paper aimed to address whether the human heart has undergone natural selection to favour endurance-based activity. To do so, unique populations were studied over a period of eight years across four continents, including chimpanzees from African sanctuaries and indigenous Tarahumara from the remote Copper Canyons. These novel cross-sectional comparisons are supplemented by longitudinal training studies to examine the complex relationship between activity pattern, haemodynamic load and cardiac remodelling. The data generated provide a unique insight into our evolutionary journey, and provide a new perspective on how and why we develop cardiovascular disease when we disengage with exercise.
- Reserve for an output with double weighting
- No
- Additional information
- -
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -
