Aging of the skeletal muscle extracellular matrix drives a stem cell fibrogenic conversion
- Submitting institution
-
The University of Leicester
- Unit of assessment
- 12 - Engineering
- Output identifier
- 1511
- Type
- D - Journal article
- DOI
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10.1111/acel.12578
- Title of journal
- Aging Cell
- Article number
- -
- First page
- 518
- Volume
- 16
- Issue
- 3
- ISSN
- 1474-9718
- Open access status
- Compliant
- Month of publication
- March
- Year of publication
- 2017
- URL
-
-
- Supplementary information
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https://doi.org/10.1111/acel.12578
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
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13
- Research group(s)
-
-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- A novel image-based tool was developed to investigate implications of skeletal muscle (SM) extracellular matrix (ECM) on fibre production and stiffness of muscular stem cells (MuSCs). This is significant in developing novel therapeutic targets to enhance SM regenerative capacity in aged population. MuSCs seeded onto aged ECM displayed increased fibre production and muscle stiffness. This work won Aging Cell Best Paper Prize 2017, awarded by the Anatomical Society. It has influenced analysis and modelling of organoids (Gartner, San Francisco), bone healing engineering (Tuan, Pittsburgh) and pelvic floor muscles mechanics (Alperin, San Diego).
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -