Bile Salts Caught in the Act: From Emulsification to Nanostructural Reorganization of Lipid Self-Assemblies
- Submitting institution
-
University of Central Lancashire
- Unit of assessment
- 12 - Engineering
- Output identifier
- 24758
- Type
- D - Journal article
- DOI
-
10.1021/acs.langmuir.8b02343
- Title of journal
- Langmuir
- Article number
- -
- First page
- 13626
- Volume
- 34
- Issue
- 5
- ISSN
- 0743-7463
- Open access status
- Compliant
- Month of publication
- November
- Year of publication
- 2018
- URL
-
-
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- Yes
- Number of additional authors
-
3
- Research group(s)
-
E - Centre for Smart Materials
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- This work demonstrates dual role of bile salts, first, as interfacial stabilizers and second, towards decreasing interfacial curvature of lipid phases causing simpler structures, like vesicles, to form. The latter role has been reported for the first time. Both roles are now being recognised to be crucial for digesting highly complex and viscoelastic self-assemblies of food lipids. This work inspired us to develop bile salt and lipid-based nano-formulations for enhanced solubility of poorly soluble active pharmaceutical ingredients and their increased permeation for topical applications, which are under evaluation at UCLan for patent applications.
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -
